Bortezomib (marketed under the brand name Velcade) is a targeted therapy used primarily in the treatment of multiple myeloma and mantle cell lymphoma. As a proteasome inhibitor, it works by blocking specific proteins in cancer cells, which prevents them from growing and eventually leads to cell death.
If your oncologist has prescribed Bortezomib, understanding the administration, storage, and side effect management is crucial for your treatment journey.
How is Bortezomib Administered?
Bortezomib is not a pill; it is a lyophilized (freeze-dried) powder that must be reconstituted by a healthcare professional. It is typically administered in two ways:
- Subcutaneous (SC) Injection: Injected under the skin (usually in the thigh or abdomen).
- Intravenous (IV) Infusion: Injected directly into a vein.
Note: The subcutaneous route is often preferred by clinical teams as it may reduce the risk of peripheral neuropathy (nerve pain) compared to IV administration.
Key Safety Information & Precautions
Before beginning treatment, ensure your medical team is aware of the following:
- Existing Nerve Issues: Tell your doctor if you have a history of numbness, tingling, or burning in your hands or feet.
- Viral History: Bortezomib can reactivate the shingles virus (Herpes Zoster). Many doctors prescribe an antiviral medication alongside treatment.
- Hydration: Maintaining adequate hydration is vital during the days you receive your injection to protect kidney function.
Managing Common Side Effects
While effective, Bortezomib can cause side effects. Being proactive helps manage them:
- Gastrointestinal Distress: Nausea, diarrhea, or constipation are common. Diet adjustments or over-the-counter medications recommended by your pharmacist can help.
- Fatigue: Most patients experience significant tiredness. Plan your schedule to allow for rest on injection days.
- Blood Counts: This medication can lower platelets and white blood cell counts, increasing the risk of bruising or infection.
Proper Storage and Handling
If you are picking up your medication from a specialty pharmacy to take to your clinic:
- Temperature: Store the vial at controlled room temperature ($20^\circ\text{C}$ to $25^\circ\text{C}$ or $68^\circ\text{F}$ to $77^\circ\text{F}$).
- Light Protection: Keep the vial in its original carton to protect it from light.
- Safety: Keep out of reach of children and pets.
Fulfilling Your Prescription
At Haroshee, we understand that managing a complex diagnosis requires more than just a medication—it requires a partner. We specialize in oncology medications and offer:
- Verified Sourcing: We provide authentic Bortezomib 3.5mg vials from regulated manufacturers.
- Pharmacist Consultation: Our licensed pharmacists are available to discuss your dosage and side effect management.
- Secure Delivery: We ensure your specialty medications are handled with the highest standards of safety and care.
Disclaimer: This guide is for educational purposes only and does not replace professional medical advice. Always consult your oncologist or a licensed healthcare provider before starting or changing your treatment plan. A valid prescription is required to fulfill this medication.
Frequently Asked Questions About Bortezomib (Velcade)
What is the most common side effect of Bortezomib?
The most frequently reported side effect is peripheral neuropathy, which feels like numbness, tingling, or a “pins and needles” sensation in the hands or feet. If you notice these symptoms, inform your care team immediately, as they may adjust your dosage or switch your administration from intravenous (IV) to subcutaneous (under the skin) to reduce the impact.
How often will I receive a Bortezomib injection?
Treatment schedules vary, but a common cycle involves injections on Days 1, 4, 8, and 11, followed by a 10-day rest period. This 21-day period is considered one “cycle.” Your oncologist will determine the total number of cycles based on how your body responds to the medication.
Can I take vitamins or supplements while on this medication?
You should avoid Green Tea and high doses of Vitamin C while receiving Bortezomib, as some studies suggest they may interfere with how the drug works. Always provide your pharmacist with a full list of any herbal supplements or over-the-counter vitamins you are taking.
Why do I need to be careful about Shingles (Herpes Zoster)?
Bortezomib can weaken the immune system, which may cause a dormant shingles virus to reactivate. It is common for doctors to prescribe a preventative antiviral medication (like acyclovir) to be taken throughout your treatment cycle.
Does Bortezomib cause hair loss?
Unlike many traditional chemotherapies, Bortezomib does not typically cause significant hair loss. While some thinning can occur, it is much less common than with other cancer treatments.
How should I prepare for my injection day?
- Stay Hydrated: Drink plenty of water the day before and the day of your treatment.
- Monitor Blood Pressure: If you have a history of low blood pressure, move slowly when standing up, as Bortezomib can cause dizziness.
- Check Your Counts: Ensure you’ve completed any required blood tests (CBC) before your appointment to check your platelet and white blood cell levels.
